1 edition of Toxicology and Carcinogenesis Studies Of 1, 3-Butadiene (Cas No.106-99-0) In B6C3F1 Mice,... Technical Report Series... No.282... U.S. Department. Of Health and Human Services... 1995. found in the catalog.
Toxicology and Carcinogenesis Studies Of 1, 3-Butadiene (Cas No.106-99-0) In B6C3F1 Mice,... Technical Report Series... No.282... U.S. Department. Of Health and Human Services... 1995.
Written in English
|Contributions||National Cancer Institute (U.S.)|
Animal studies have reported tumors at a variety of sites from inhalation exposure to 1,3-butadiene. (1,5,6) 1,3-Butadiene is metabolized into genotoxic metabolites by experimental animals and humans. (1) EPA has classified 1. Symposium on the toxicology, carcinogenesis and human health aspects of 1,3-butadiene, April , , Research Triangle Park, NC. Authors NIOSH.
toxicology and carcinogenesis. studies of 1-bromopropane (cas no. ) in f/n rats and b6c3f1 mice (inhalation studies) national toxicology program. p.o. box research triangle . NTP. TR 1,3-Butadiene (). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). Accessed htt.
A quantitative risk assessment of 1,3-butadiene () carcinogenicity based on data obtained in a study of mice exposed to low butadiene concentrations was performed. Data were taken from the . Table Sites of increased incidences of neoplasms in the 2 year inhalation studies of 1,3-butadiene, isoprene, and chloroprene in rats and mice Table Quantitative comparison of carcinogenic .
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1,3-Butadiene, a high-production volume chemical used largely in the manufacture of synthetic rubber, is a multiple organ carcinogen in rats and mice. In inhalation studies conducted in mice by the National Toxicology Program, high rates of early lethal lymphomas Cited by: Inhalation carcinogenesis studies of 1,3-butadiene wereconducted by exposing groups of 50 male and female B6C3F1 mice 6 hours per dayfor 5 days per week to air containing the test chemical at concentrations of 0(chamber controls),or 1.
NTP () Toxicology and carcinogenesis studies of 1,3-butadiene (CAS No. ) in B6C3F1 mice (inhalation studies). In: National Toxicology Program TR No.pp. 1–, National Cited by: Melnick R.L., Huff J.E., Miller R.A. () Toxicology and Carcinogenicity of 1,3-Butadiene.
In: Mohr U., Bates D.V., Dungworth D.L., Lee P.N., McClellan R.O., Roe F.J.C. (eds) Assessment of Inhalation Cited by: 5. 1,3-Butadiene, a high-production volume chemical used largely in the manufacture of synthetic rubber, is a multiple organ carcinogen in rats and mice. In inhalation studies conducted in mice by the National Toxicology Cited by: 1,3-Butadiene, a high-production volume chemical used largely in the manufacture of synthetic rubber, is a multiple organ carcinogen in rats and mice.
According to the ATSDR Toxicological Profile for 1,3-butadiene, the mean concentration of 1,3-butadiene in outdoor air can range from – ppb in urban settings . The OSHA mandates that levels of 1,3-butadiene not exceed an average of 1 ppm over an 8-h workday [19,].
The primary biogenic source of 1,3. 1. Public Health Statement, KB What is this substance. What happens to it when it enters the environment. How might I be exposed to it. How can it enter and leave my body.
How can it affect my health. How can it affect children. Principles of Carcinogenesis 2. DNA Reactive and Non- DNA Reactive Carcinogens 3. Methods for Screening for Carcinogenicity 4.
Model of Carcinogenesis Incorporating DNA Damage and Increased Cell Proliferation 5. Mode of Action Analysis and Extrapolation of In Vitro and Animal Studies. NTP Toxicology and Carcinogenesis Studies of 1,3-Butadiene (CAS No. ) in B6C3F1 Mice (Inhalation Studies).
National Institute of Environmental Health Sciences (NIEHS), (May ). national toxicology program technical report series no. toxicology and carcinogenesis studies of 1,s-butadiene (cas no.
) in b6c3f1 mice. National Toxicology Program. 1,3 Butadiene, Report on Carcinogens, Fourteenth Edition. Triangle Park, NC: National Institute of Environmental Health and Safety, Also available online.
1,3-Butadiene: Target Organs and Levels of Evidence for TR Toxicology and Carcinogenesis Studies of 1,3-Butadiene (CASRN ) in B6C3F1 Mice (Inhalation Studies) Chemical (Study Title).
Symposium Overview: Toxicology, Carcinogenesis, and Human Health Aspects of 1,3-Butadiene Article (PDF Available) in Environmental Health Perspectives 86 June with 89 Reads.
At a Glance. 1,3-butadiene is a chemical processed from petroleum. It is most commonly used in the production of rubber. 1,3-butadiene has beenlisted as a human carcinogenby the National Toxicology. Toxicology and carcinogenesis studies of 1,3-butadiene (CAS No.
) in B6C3F1 mice (inhalation studies). National Toxicology Program (NTP), U.S. Public Health Service, US Department of Health and Human Services.
1, 3-Butadiene (BD), a compound used extensively in the rubber industry, is carcinogenic in male and female Sprague-Dawley rats after chronic exposures to and p.p.m. In terms of incidence of tumors the majority were in mammary tissue, thus the incidence of tumors in female rats exceeded that in males in chronic carcinogenicity studies.
1,3-Butadiene is a chemical made from the processing of petroleum. It is the 36th highest volume chemical produced in the United States. It is a colorless gas with a mild gasoline-like odor. About 75% of the manufactured 1,3-butadiene is used to make synthetic rubber.
Synthetic rubber is widely used for tires on cars and trucks. National Toxicology Program Toxicology and Carcinogenesis Studies of 1,3-Butadiene (CAS No. ) in B6C3F1 Mice (Inhalation Studies). NTP TRNIH Publication No.
Toxicology and carcinogenesis studies of dietary titanium dioxide‐coated mica in male and female Fischer rats. Journal of Toxicology and Environmental Health: Vol. 28, No. 4, pp. Numerous epidemiological studies have established 1,3-butadiene as a human carcinogen with primary target sites of the blood and the lymphatic system [19,–].
A dose–response relationship between 1.Abstract # Exposure to the Genotoxic Chemical 1,3-butadiene Confers Tissue- and Strain-specific Alterations in microRNA expression.
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